Cefixime, Pharmacology and Indication

Pharmacology of Cefixime, Cefixime is a semi synthetic antibiotic cephalosporin 3rd generation for oral administration. Cefixime has board spectrum activity against gram positive and gram negative microorganisms, and extremely stable to beta lactamase producing organisms. Bactericidal action of cefixime results from inhibition of cell well synthesis. Cefixime Chemical name is (6R,7R)-7-{[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino}-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
Cefixime is about 40-50% absorbed from the gastrointestinal tract, whether
administered with or without food. It produces an average peak concentration of
approximately 3.7 μg/ml (range 1.3-7.7 μg/ml). The peak serum concentration is
attained between 2-6 hours of administration. Approximately 50% of the
absorbed dose is excreted unchanged in urine within 24 hour.
Indication :
1. Otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes.
2. Phryngitis and tonsilitis
3. Acute Bronchitis and acute Exacerbations of Chronics Bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains).
4. Urinary Tract Infection
5. Uncomplicated Gonorrhea ( Cervical / Urethral ) caused by Neisseria gonorrhoeae
Contraindication :
- Hypersensitivity to Chephalosporin
- Patients with impaired renal function, required modification of dosage depending on the degree of impairment.