Griseofulvin is a fungistatic antibiotic, mainly effective on a specific group of fungi, Dermatophytes ( Trichopyton, Microsporum and Epidermophyton ). It inthibits fungal cell mitosis in causing disruption of the mitotic spindle structure, thereby arresting the metaphase of cell division.
Following oral administration, Griseofulvin reaches the skin, hair an nails and be deposited in the keratin precursor cells, it has a greater affinity for diseased tissue. Griseofulvin are gradually exfoliated and replaced by non infected tissue. The drug is tightly bound to the new keratin, which becomes highly resistant to fungal invasions. Griseofulvin Chemical name is - (2S,6'R)- 7-chloro- 2',4,6-trimethoxy- 6'-methyl- 3H,4'H-spiro [1-benzofuran- 2,1'-cyclohex[2]ene]- 3,4'-dione.
Griseofulvin treatment of ringworm infections of the skin, hair and nails, like tinea corporis, tinea pedis, Tinea cruris, Tinea barbae, tinea capitis, tinea unguinum when caused by one or more of dermatophytes fungi.
Side Effect: Known side effects of Griseofulvin include ; Can reduce the effectiveness of oral contraceptives as it a cytochrome p450 enzyme inducer,Impairment of performance of routine activities, Loss of taste sensation, Tingling in the hands or feet, Upper abdominal pain, vomiting and Diarrhea.
Griseofulvin profiles: Plasma protein binding is 80%, Maximal plasma concentration is 0,5 - 2
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